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Alveolar abnormalities are changes within the tiny air sacs in the lungs, known as alveoli. Alveoli allow oxygen to enter the blood. They are very thin to let oxygen move from the lungs to the blood vessels, and for carbon dioxide to be removed from the blood vessels to the lungs. Once this occurs oxygen and carbon dioxide alternate don't happen normally and result in completely different disorders. It requires many alveoli to be destroyed earlier than abnormalities in carbon dioxide and oxygen levels do happen. These changes will be momentary or permanent, depending on the illness. Albertine KH, Ramirez MI, Morty RE. Anatomy. In: Broaddus VC, Ernst JD, King TE, et al, eds. Murray and Nadel's Textbook of Respiratory Medicine. Hall JE, Hall ME. Respiratory insufficiency - pathophysiology, diagnosis, oxygen therapy. In: Hall JE, Hall ME, eds. Guyton and Hall Textbook of Medical Physiology. Updated by: Denis Hadjiliadis, MD, MHS, Paul F. Harron, Jr. Professor of Medicine, Pulmonary, Allergy, and important Care, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA. Also reviewed by David C. Dugdale, MD, Medical Director, Brenda Conaway, Editorial Director, and the A.D.A.M.
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