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The term "adrenal fatigue" was coined by James Wilson to describe the hypoadrenalism seen throughout chronic stress. Wilson proposes that the adrenal glands become worn out after extreme long-term stress and lose their skill to produce cortisol. However that doesn't fit the science. Although one study found that some CFS patients have shrunken adrenal glands, most patients have normal adrenal glands which produce regular amounts of cortisol. Research as an alternative exhibits that CFS patients have an abnormally low HPA axis response to stress, in addition to an abnormally low cortisol awakening response (which itself is thought to be an excellent indication of HPA axis responsiveness, as waking up is actually a mild stressor for the HPA axis). All the analysis shows that the hypocortisolism is central in nature, i.e. managed by the mind, quite than any problem with the adrenal glands themselves. Sports science analysis by Tim Noakes and different researchers has proven that fatigue is actually an emotion generated within the mind, which acts to prevent damage to the physique when the mind perceives that further exertion could be dangerous.
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