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The term "adrenal fatigue" was coined by James Wilson to explain the hypoadrenalism seen during chronic stress. Wilson proposes that the adrenal glands grow to be worn out after extreme lengthy-term stress and lose their potential to provide cortisol. However that does not fit the science. Although one study discovered that some CFS patients have shrunken adrenal glands, most patients have normal adrenal glands which produce regular quantities of cortisol. Research instead shows that CFS patients have an abnormally low HPA axis response to stress, in addition to an abnormally low cortisol awakening response (which itself is thought to be a good indication of HPA axis responsiveness, as waking up is basically a mild stressor for the HPA axis). All of the research exhibits that the hypocortisolism is central in nature, i.e. controlled by the mind, relatively than any downside with the adrenal glands themselves. Sports science analysis by Tim Noakes and other researchers has proven that fatigue is definitely an emotion generated in the mind, which acts to prevent damage to the physique when the mind perceives that additional exertion could be harmful.
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